AB0326 USEFULNESS OF THE INTIMA-MEDIA THICKNESS INDEX BY CAROTID DOPPLER IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS OF HOSPITAL DOCENTE PADRE BILLINI, DOMINICAN REPUBLIC

Background: Systemic lupus erythematosus (SLE) is a multisistemic autoimmune disease. 1 There are studies where the increase in thickness of intimate/media average carotid (IMT) valued, most have shown 2 . Cardiovascular disease one leading causes morbidity, especially due to its precocity, which occurs women during fertile potential, associated with higher prevalence cardiovascular (CVD), accelerated atherosclerosis 3,4,5 Patients rheumatic diseases an increased risk systemic inflammation and endothelial dysfunction, promotes 2. Values below 0.9mm IMT considered normal. Objectives: Evaluate patients erythematosus. Methods: Prospective, Observational, cross-sectional study. Carotid Doppler was performed on outpatient clinic diagnosis SLE from November 2019 2020 rheumatology service Hospital Docente Padre Billini healthy controls. Inclusion criteria: > 18 years old, ACR 2007 classification criteria, Doppler, measurement IMT. Controls without disease, matched by sex age. The data analyzed SPSS V23. Results: 116 SLE. 95 met inclusion criteria;95 controls were included. 97.8% female. Average 6.23 years. 71. 57% (68) use glucocorticoids, antimalarials 70.52% (67), 38.94% (37) mofetil mycophenolate, 20% (19) methotrexate, 11. (11) rituximab, 5.26% (5) azathioprine, 1.05% (1) cyclosporine, cyclophosphamide 0.86% tacrolimus. Dyslipidemia (63.1%) (73), obesity 34.7% (33), high blood pressure 23.1% (22), diabetes 3.44% (4), smokers 0% (0). doppler showed 17.89% (17) atheromatous plates, 29.4% calcified 36.84% (7) plates. activity rate using SLEDAI 68.96% (80) activity, 13.79% (16) low, 11.20% (13) moderate, 6.03% activity. 78% (75) had mean (SD) 2.15mm (0.99). About control 71.57% IMT, 1.27mm (1.07) (p-0.046). Conclusion: Our study found that increase. ratio vast majority our low Alterations glucocorticoid use. no significant difference intima-media index respect group. We suggest realization despite being for evaluation monitoring risk. References: [1]Hernández Muñiz, Y, Guibert Toledano, Z. Reyes Llerena, G., 2015. Correlation C Reactive Protein Figures Atherosclerosis Lupus Erythematosus. [2]Saldarriaga Rivera, L., Ventura Ríos, Hernández Díaz, C. Pineda Villaseñor, C., 2016. Measurement intimate-half carotid: utility ultrasound subcline diseases. Literature review. Rev Col Reum, 23(2), pp.92-101. [3]Telles, R., Lanna, Ferreira, Souza, A., Navarro, T. Ribeiro, 2008. atherosclerotic alterations treated at Brazilian university setting. Lupus, 17(2), pp.105-113. [4]Nienhuis, H., Leeuw, K., Bijzet, J., van Doormaal, Roon, Smit, Graaff, Kallenberg, Bijl, M., 2010. Small artery elasticity decreased intima media thickness. Arthritis Research & Therapy , 12(5), p.R181. [5]Frerix et al. 2014, 16: R54 Disclosure Interests: None declared